Gold Nanoparticle Size Selection for LFA & IVD: A Practical Guide

Summary of the trade-off

 Property Smaller particles (around 20 nm) Larger particles (80–100 nm)
Color Cherry red Wine to violet
Brightness per particle Lower Substantially higher
Speed through membrane Faster Slower
Colloidal stability Easier to maintain Requires more careful handling
Antibody needed per particle Less More
Access to crowded surfaces Better Reduced by sterric hindrance
Best suited to

Abundant targets, competitive formats, crowded surfaces

Low-abundance targets, maximum line intensity

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